ETIOLOGY:
- DIABETES MELLITUS
- INCREASED GLUCOSE LEVELS
- INCREASED GLOMERULAR FILTRATION RATE WHICH MAY LEAD TO MICROALBUMINEMIA
- ENLARGEMENT OF GLOMERULAR CAPILLARY
- INCREASED PROTEIN CONTENT WHICH LEADS TO:
- INCREASED BUN
- INCREASED CREATININE
4. INCREASED ENDOCYTOSIS
5.
- RENIN
- ANGIOTENSIN
- ANGIOTENSIN I
- ANGIOTENSIN II
- ALDOSTERONE (ADRENAL CORTEX)
- Na ABSORPTION AND WATER RETENTION
- HYPERTENSION
6.
- DECREASED ABILITY TO CONCENTRATE URINE
- HYPOKALEMIA
- BRAIN DYSFUNCTION AS MANIFESTED IN HYPOKALEMIA,
- ABDOMINAL DYSFUNCTION
7.
- DECREASE ABILITY OF KIDNEY TO REGULATE Na
- HEMODILUTION OF Na BY WATER
- HYPONATREMIA
- HEADACHE
- MUSCLE WEAKNESS
- FATIGUE
- APATHY
- ANOREXIA
- NAUSEA AND VOMITING
source:
Porth, C. (2007) Essentials of Pathophysiology: Concept of Altered Health States. Lippincott
