DIABETIC NEUROPATHY

ETIOLOGY:

• DIABETES MELLITUS
• INCREASED GLUCOSE LEVELS

1. INCREASED GLOMERULAR FILTRATION RATE WHICH MAY LEAD TO MICROALBUMINEMIA
2. ENLARGEMENT OF GLOMERULAR CAPILLARY
3. INCREASED PROTEIN CONTENT WHICH LEADS TO:

• INCREASED BUN
• INCREASED CREATININE

4. INCREASED ENDOCYTOSIS

5.

1. RENIN
2. ANGIOTENSIN
3. ANGIOTENSIN I
4. ANGIOTENSIN II
5. ALDOSTERONE (ADRENAL CORTEX)
6. Na ABSORPTION AND WATER RETENTION
7. HYPERTENSION

6.

1. DECREASED ABILITY TO CONCENTRATE URINE
2. HYPOKALEMIA
3. BRAIN DYSFUNCTION AS MANIFESTED IN HYPOKALEMIA,
4. ABDOMINAL DYSFUNCTION

7.

1. DECREASE ABILITY OF KIDNEY TO REGULATE Na
2. HEMODILUTION OF Na BY WATER
3. HYPONATREMIA
4. HEADACHE
5. MUSCLE WEAKNESS
6. FATIGUE
7. APATHY
8. ANOREXIA
9. NAUSEA AND VOMITING

source:

Porth, C. (2007) Essentials of Pathophysiology: Concept of Altered Health States. Lippincott